Calaptin 80mg Tablet

Interactions

Drug :- alpha blockers, antihypertensives, general anesthetics hydrocarbon, prazosin: Hypotensive effects.

aspirin: Increased bleeding time.

beta blockers: Increased risk of heart failure, hypotension, and severe bradycardia.

calcium supplements: Decreased response to verapamil.

carbamazepine, cyclosporine, theophylline, valproate: Increased risk of toxicity from these drugs.

cimetidine: Decreased metabolism and increased blood level of verapamil.

clonidine: Increased risk of severe sinus bradycardia.

cyclophosphamide, oncovin, procarbazine, prednissone COPP regimen, vindesine, adriamycin, cisplatin VAC regimen: Decreased verapamil absorption.

dantrolene: Increased risk of hyperkalemia and myocardial depression.

digoxin: Increased blood digoxin level and risk of digitalis toxicity.

disopyramide, flecainide: Additive negative inotropic effects.

doxorubicin: Increase plasma doxorubicin level.

erythromycin, ritonavir: Increased blood verapamil level.

lithium: Increased risk of neurotoxicity.

neuromuscular blockers: Prolonged recovery from neuromuscular blockade.

NSAIDs, sympathomimetics: Decreased antihypertensive effect of verapamil.

paclitaxel: Decreased paclitaxel clearance.

phenobarbital: Increased verapamil clearance.

procainamide: Increased QT interval, additive negative inotropic effects.

protein-bound drugs hydantoins, salicylates, sulfonamides, sulfonylureas, and warfarin and other oral anticoagulants: Altered blood levels of these drugs.

quinidine: Increased risk of quinidine toxicity, increased QT interval, additive negative inotropic effects.

rifampin: Decreased bioavailability of oral verapamil.

telithromycin: Increased risk of bradyarrhythmias, hypotension, and lactic acidosis.

Food :- grapefruit juice: Increased verapamil level.

Activity :- alcohol use: Increased blood alcohol level and prolonged CNS effect.