Cordarone 100mg Tablet

Interactions

Drug :- anticoagulants: Increased anticoagulant response and possibly serious bleeding azole antifungals, fluoroquinolones, macrolide.

antibiotics: Increased risk of prolonged QT interval and life-threatening arrhythmias.

beta blockers: Increased serum levels of beta blockers with increased risk of AV block, hypotension, and bradycardia.

calcium channel blockers: Increased serum levels of these drugs and increased risk of AV block, bradycardia, and hypotension cholestyramine, phenytoin, rifampin, St. John's wort: Decreased amiodarone level.

cimetidine: Increased amiodarone level.

clopidogrel: Increased risk of ineffective inhibition of platelet aggregation.

cyclosporine: Increased cyclosporine level dextromethorphan, methotrexate, phenytoin: Increased serum levels of these drugs and increased risk of toxicity if amiodarone is taken orally for more than 2 weeks.

digoxin: Increased serum digoxin level and risk of digitalis toxicity diltiazem, propranolol, verapamil: Increased risk of hemodynamic and electrophysiologic abnormalities disopyramide: Increased serum disopyramide level with QT prolongation and increased risk of arrhythmias.

fentanyl: Increased serum fentanyl level with increased risk of bradycardia, decreased cardiac output, and hypotension.

flecainide: Increased serum flecainide level.

HMG-CoA reductase inhibitors such as atorvastatin and simvastatin: Increased risk of myopathy and rhabdomyolysis.

hydantoins: Increased serum hydantoin level with long-term use and reduced serum amiodarone level.

lidocaine: Increased serum lidocaine level and risk of seizures and bradycardia loratadine, trazodone: Increased risk of QTinterval prolongation and torsades de pointes.

potassium- and magnesium-depleting drugs: Increased risk of hypokalemia and hypomagnesemia.

procainamide: Increased serum procainamide or N-acetylprocainamide.

levelquinidine: Increased serum quinidine level with risk of life-threatening arrhythmias.

ritonavir: Increased serum amiodarone level with increased risk of cardiotoxicity.

theophylline: Increased serum theophylline level, increased risk of theophylline toxicity.

warfarin: Increased PT and risk of bleeding.

Food :- grapefruit juice: Increased amiodarone level.