Norten 10mg Tablet

Interactions

Drug :- ACE inhibitors: Increased risk of hypotension, especially in presence of acute MI.

allergen immunotherapy, allergenic extracts for skin testing: Increased risk of serious systemic adverse reactions or anaphylaxis.

amiodarone: Additive depressant effects on.

conduction, negative inotropic effects anesthetics hydrocarbon inhalation:Increased risk of myocardial depression and hypotension beta blockers: Additive beta blockade effects.

bupivacaine, lidocaine, mepivacaine: Decreased clearance of these drugs, possibly increased risk of toxicity calcium channel blockers, clonidine, diazoxide, guanabenz, resperpine, other hypotension-producing drugs: Additive hypotensive effect and, possibly, other beta blockade effects.

catecholamine-depleting drugs, such as reserpine: Increased risk of hypotension, bradycardia, vertigo, syncope, and orthostatic hypotension.

cimetidine: Possibly interference with propranolol clearance.

digitalis glycosides: Increased risk of bradycardia.

diltiazem: Increased risk of bradycardia, hypotension, high-degree heart block, and heart failure.

dobutamine, isoproterenol: Reversed effects of propranolol.

doxazosin, terazosin: Increased risk of orthostatic hypotension.

epinephrine: Increased risk of uncontrolled hypertension.

estrogens: Decreased antihypertensive effect of propranolol.

fentanyl, fentanyl derivatives: Possibly increased risk of initial bradycardia after induction doses of fentanyl or a derivative with long-term propranolol use.

glucagon: Possibly blunted hyperglycemic response.

insulin, oral antidiabetic drugs: Possibly impaired glucose control, masking of tachycardia in response to hypoglycemia.

MAO inhibitors, tricyclic antidepressants: Increased risk of significant hypertension.

neuroleptic drugs: Increased risk of hypotension and cardiac arrest.

neuromuscular blockers: Possibly potentiated and prolonged action of these drugs.

NSAIDs: Possibly decreased hypotensive effects.

phenothiazines: Increased blood levels of both drugs.

phenytoin: Additive cardiac depressant effects with parenteral phenytoin.

prazosin: Increased risk of first-dose hypotension.

propafenone: Increased blood level and half life of propranolol.

quinidine: Increased propranolol level, resulting in higher degrees of beta blockade and orthostatic hypotension.

sympathomimetics, xanthines: Possibly mutual inhibition of therapeutic effects.

thyroxine: Possibly decreased T3 level.

verapamil: Increased risk of bradycardia, heart failure, and cardiovascular collapse.

warfarin: Increased risk of bleeding.

Activity :- alcohol: Possibly increased plasma propranolol level.

nicotine chewing gum, smoking cessation, smoking deterrents: Increased therapeutic effects of propranolol.