Unicontin-E 400mg Tablet CR

Interactions

Drug :- adenosine: Decreased adenosine effectiveness allopurinol, cimetidine, ciprofloxacin, clarithromycin, disulfiram, enoxacin, erythromycin, fluvoxamine, interferon alpha human recombinant, methotrexate, mexiletine, pentoxifylline, propafenone, propranolol, tacrine, thiabendazole, ticlopidine, troleandomycin, verapamil: Increased blood theophylline level and risk of toxicity.

aminoglutethimide, carbamazepine, isoproterenol I.V., moricizine, oral contraceptives containing estrogen, phenobarbital, phenytoin, rifampin: Decreased blood theophylline level and possibly drug effectiveness.

benzodiazepines: Possibly reversal of benzodiazepine sedation.

beta blockers: Possibly decreased bronchodilator effect of theophylline.

ephedrine: Increased adverse effects, including insomnia, nausea, and nervousness.

halothane anesthetics: Increased risk of ventricular arrhythmias.

ketamine: Lowered seizure threshold.

lithium: Decreased lithium effectiveness.

neuromuscular blockers: Possibly antagonized neuromuscular blockade.

sucralfate: Decreased absorption of oral theophylline.

Food :- high-carbohydrate, low-protein diet: Possibly decreased theophylline elimination.

low-carbohydrate, high-protein diet, daily intake of charbroiled beef: Possibly increased theophylline elimination.

Activity :- alcohol use: Increased blood theophylline level and risk of toxicity.

smoking: Increased drug clearance, decreased drug effectiveness.